Chronic recurrent multifocal osteomyelitis: 17 case reports and literature review

Results CRMO primarily affects girls with a mean age at onset of 8.5 years and a mean time to diagnosis of 8.5 months. Most patients were diagnosed in less than 1 month, but 2 cases presented a delay due to atypical presentation. At onset, 14 patients had inflammatory pain and 6 local swelling and fever. The lower limbs were predominantly affected, followed by the axial skeleton, the upper limbs and lastly by the mandible. Laboratory parameters provided non-specific information on CRMO. Radiographic studies were needed to exclude other pathologies. The diagnosis should be reached by isotope bone scanning or by magnetic resonance imaging. In doubt case bone biopsy was request to confirm the diagnosis.